Structural elucidation and functional analysis of insulin-like growth factor binding protein-3 domains

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Translating information from the human genome project into information about cell function is a major challenge in the post-genome era. The multifunctional insulin-like growth factor binding protein-3 (IGFBP-3), a member of a multigene superfamily, regulates cell growth and function through numerous signalling pathways. This project will provide structural information about IGFBP-3 as a prototype for the superfamily, and using a combination of methodologies will unravel mechanisms of IGFBP-3 action. The project will advance understanding of IGFBP-3 and superfamily functions, and provide both benefits in international research leadership and economic and health benefits in animal and human growth and metabolism.