Structural elucidation and functional analysis of insulin-like growth factor binding protein-3 domains

胰岛素样生长因子结合蛋白3结构域的结构阐明和功能分析

• 批准号: DP0345171
• 负责人: Prof Robert Baxter
• 金额: $ 7.47万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-08-29 至 2006-08-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0345171
• 关键词: Structural; elucidation; functional; analysis; insulin

Translating information from the human genome project into information about cell function is a major challenge in the post-genome era. The multifunctional insulin-like growth factor binding protein-3 (IGFBP-3), a member of a multigene superfamily, regulates cell growth and function through numerous signalling pathways. This project will provide structural information about IGFBP-3 as a prototype for the superfamily, and using a combination of methodologies will unravel mechanisms of IGFBP-3 action. The project will advance understanding of IGFBP-3 and superfamily functions, and provide both benefits in international research leadership and economic and health benefits in animal and human growth and metabolism.

将人类基因组计划的信息转化为细胞功能的信息是后基因组时代的一个重大挑战。多功能胰岛素样生长因子结合蛋白-3（IGFBP-3）是多基因超家族的成员，通过多种信号通路调节细胞生长和功能。该项目将提供有关IGFBP-3的结构信息作为超家族的原型，并使用组合的方法将解开IGFBP-3的作用机制。该项目将促进对IGFBP-3和超家族功能的理解，并在动物和人类生长和代谢方面提供国际研究领导力和经济和健康效益。