How the repair of DNA damage is regulated by IGFBP-3, a protein at the crossroads between cell death and survival.

IGFBP-3（一种处于细胞死亡和生存十字路口的蛋白质）如何调节 DNA 损伤的修复。

• 批准号: DP140100137
• 负责人: Prof Robert Baxter
• 金额: $ 27.24万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-03-06 至 2017-03-05
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100137
• 关键词: How; repair; DNA; damage; regulated

This project aims to discover how a protein called IGFBP-3, which is found in essentially all vertebrates, contributes to the repair of damaged DNA, and to the fate of cells after DNA damage. This is important because all cells are thought to suffer DNA damage many times each day, caused by both environmental and internal events. If unrepaired, this damage can permanently affect a cell’s genetic make-up. If successful, this research will reveal which other proteins IGFBP-3 interacts with, and how it acts at the crossroads between cell survival or death. This information will advance fundamental understanding about important cellular processes and might in future be applied to improving the response of some diseases to treatment.

该项目旨在发现一种名为IGFBP-3的蛋白质如何有助于DNA损伤的修复，以及DNA损伤后细胞的命运。IGFBP-3基本上存在于所有脊椎动物中。这一点很重要，因为所有细胞都被认为每天都会遭受多次DNA损伤，这是由环境和内部事件造成的。如果不加以修复，这种损伤可能会永久性地影响细胞的基因构成。如果成功，这项研究将揭示IGFBP-3与哪些其他蛋白质相互作用，以及它如何在细胞生存或死亡的十字路口发挥作用。这些信息将促进对重要细胞过程的基本理解，并可能在未来应用于改善某些疾病对治疗的反应。