Synthesis, characterization, genotoxicity and systemic toxicity of Polycyclic Polyprenylated Acyl phloroglucinols (PPAPs)

在“印度-德国医学研究资助倡议——毒理学”框架内，计划中的新PPAP衍生物不仅要调查其活性，而且首先要调查其在各种动物模型和细胞培养中的毒性和耐受性。我们已经建立了两种昆虫模型，一种是德国t<s:1>宾根的蜡蛾幼虫模型，另一种是印度Kerela的果蝇模型。在这两种模型中，首先对化合物进行测试，只有当它们在这里没有显示出毒性活性时，才会在小鼠模型中进一步研究。通过这种方法，我们的目标是显著减少小鼠实验的数量。印度合作伙伴有一个完善的小鼠模型，这对于在哺乳动物模型中更详细地调查（不）期望的活动是必不可少的。除了理想的科学的印德伙伴关系外，我们非常关心如何长期保持和深化这种伙伴关系。Biswas工作组的Aparna Viswanathan Ammanath已经开始了第一步，她目前正在<s:1>宾根Götz工作组完成她的博士论文。因此，参与的博士生在各自的主办实验室进行为期数月的科学交流是这个德国-印度合作项目关注的问题。这将在申请期之后加强印度和德国之间的相互关系和科学联系。

Within the framework of the 'Indo-German funding initiative in medical research - Toxicology', the planned new PPAP derivatives are to be investigated not only for their activity, but above all for their toxicity and tolerability in various animal models and cell cultures. We have two established insect models, the wax moth larvae model in Tübingen, Germany, and the Drosophila model in Kerela, India. In both models the compounds are tested first and only if they do not show toxic activities here, they are further investigated in the mouse model. With this approach, we aim to significantly reduce the number of mouse experiments. The Indian partner has a well-established mouse model which is indispensable for a more detailed investigation of the (un)desired activities in the mammalian model. In addition to the ideal scientific Indo-German partnership, it is of great concern to us to maintain and deepen this partnership in the long term. A first start has already been made with Aparna Viswanathan Ammanath from the Biswas working group, who is currently completing her doctoral thesis in the Götz working group in Tübingen. It is therefore a concern of this German-Indian cooperation project that the participating PhD students engage in a scientific exchange of several months in the respective host laboratories. This would strengthen the mutual relations and consolidate the scientific connection between India and Germany also beyond the application period.