Synthesis, characterization, genotoxicity and systemic toxicity of Polycyclic Polyprenylated Acyl phloroglucinols (PPAPs)

多环聚异戊二烯酰基间苯三酚 (PPAP) 的合成、表征、遗传毒性和全身毒性

• 批准号: 536125858
• 负责人: Professor Dr. Friedrich Götz
• 金额: --
• 依托单位: Professur für Organische Chemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/536125858?language=en
• 关键词: Synthesis; characterization; genotoxicity; systemic; toxicity

Within the framework of the 'Indo-German funding initiative in medical research - Toxicology', the planned new PPAP derivatives are to be investigated not only for their activity, but above all for their toxicity and tolerability in various animal models and cell cultures. We have two established insect models, the wax moth larvae model in Tübingen, Germany, and the Drosophila model in Kerela, India. In both models the compounds are tested first and only if they do not show toxic activities here, they are further investigated in the mouse model. With this approach, we aim to significantly reduce the number of mouse experiments. The Indian partner has a well-established mouse model which is indispensable for a more detailed investigation of the (un)desired activities in the mammalian model. In addition to the ideal scientific Indo-German partnership, it is of great concern to us to maintain and deepen this partnership in the long term. A first start has already been made with Aparna Viswanathan Ammanath from the Biswas working group, who is currently completing her doctoral thesis in the Götz working group in Tübingen. It is therefore a concern of this German-Indian cooperation project that the participating PhD students engage in a scientific exchange of several months in the respective host laboratories. This would strengthen the mutual relations and consolidate the scientific connection between India and Germany also beyond the application period.

在“印度-德国医学研究-毒理学资助计划”的框架内，计划中的新PPAP衍生物不仅要研究其活性，而且首先要研究其在各种动物模型和细胞培养中的毒性和耐受性。我们有两个已建立的昆虫模型，德国图宾根的蜡螟幼虫模型和印度Kerela的果蝇模型。在这两种模型中，首先测试化合物，并且只有当它们在这里不显示毒性活性时，才在小鼠模型中进一步研究它们。通过这种方法，我们的目标是显着减少小鼠实验的数量。印度合作伙伴拥有完善的小鼠模型，这对于更详细地研究哺乳动物模型中的（非）预期活动是必不可少的。 除了理想的印德科学伙伴关系外，我们还非常关注长期保持和深化这种伙伴关系。第一个开始是与比斯瓦斯工作组的Aparna Viswanathan Ammanath一起进行的，她目前正在蒂宾根的Götz工作组完成她的博士论文。因此，这一德印合作项目的一个关切是，参与项目的博士生在各自的主办实验室进行为期数月的科学交流。这将加强相互关系，巩固印度和德国之间的科学联系，并超越申请期。