Study of environmental stress responses using amphiphiles

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Local anesthetics and antipsychotic phenothiazines cause rapid shutdowns of both actin polarization and translation initiation in yeast. Here we investigated the structure-activity relationship using a variety of amphiphiles. Structure of hydrophilic region, length of hydrophobic region, and structures of both regions were responsible for the shutdown pattern, potency, and safety, respectively. These results indicate that the yeast system can easily evaluate the clinical drugs, and provide structural basis for designing shutdown compounds.