Molecular biological studies on hybrid lethality of interspecific hybrid of genus Nicotiana

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Plant breeding based on hybridization between far-related species is important for the sustainable agriculture while climate change around the world will be more problematic. But this technique has a major drawback due to difficulties of establishing the hybrids among the parents that are reproductively isolated from each other. This research project aimed to specify the genes involved in reproductive isolation, delineate features of cell death of which induce hybrid lethality. We isolated and characterized some genes which related to hybrid cell death. We also found that hybrid lethality expresses through programmed cell death based on several cellular signaling cues.