Elucidation of fish T lymphocyte subgroup based on the CD4 family marker

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The main project target was to elucidate the CD4 family of molecules in teleost fish, with clonal ginbuna crucian carp as major fish model. This family of molecules is known to form major markers for leukocyte subpopulations, predominantly of T lymphocytes. We found a homologue of mammalian G6F, a marker of platelets, which we designated G6F-like. We could determine that G6F and G6F-like are related to the CD4 family. A monoclonal antibody against G6F-like was established and we found the molecule expressed in ginbuna thrombocytes and erythrocytes.