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Molecular mechanisms for resistance to immunosuppressive drugs in human lymphocytes stimulated with bacterial superantigen and the effects of antibiotics.

Molecular mechanisms for resistance to immunosuppressive drugs in human lymphocytes stimulated with bacterial superantigen and the effects of antibiotics.
细菌超抗原刺激的人淋巴细胞对免疫抑制药物耐药的分子机制和抗生素的作用。
批准号：
19590162
负责人：
HIRANO Toshihiko
金额：
$2.75万
依托单位：
Tokyo University of Pharmacy and Life Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2007
资助国家：
日本
项目状态：
已结题
起止时间：
2007 至 2009
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590162/
关键词：
スーパー抗原末梢血リンパ球免疫抑制薬薬物耐性機序抗菌薬ヒト末梢血単核細胞インターロイキンー2溶血性連鎖球菌カテプシンペプスタチンロキシスロマイシン免疫抑制薬耐性の分子機序インターロイキン-2ビタミンD3誘導体グルココルチコイドMAPキナーゼJNK

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中文摘要
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英文摘要
Immunosuppressive drugs are used for treatment of several autoimmune diseases, whereas some of the patients are known to show resistance to the therapeutic efficacy of the drugs. I showed in the present study that superantigen produced from infectious bacteria aggressively stimulate immune cells, which results in production of high amount of interleukin-2 (IL-2) and the drug resistance. I also found that roxithromycin can suppress the IL-2 production from superantigen-stimulated immune cells, and therefore the drug may overcome clinical resistance to immunosuppressive drugs in patients with autoimmune diseases having bacterial infection.
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会议论文
Pharmacodynamic parameters of immunosuppressive drugs are not correlated with age, duration of dialysis, percentage of lymphocytes or lymphocyte stimulation index in renal transplant recipients.
免疫抑制药物的药效参数与肾移植受者的年龄、透析时间、淋巴细胞百分比或淋巴细胞刺激指数无关。
DOI： --
发表时间： 2008
期刊： Biol Pharm Bull 31(11)
影响因子： --
作者： [Sugiyama K, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Tasaki M, Takahashi K, Saito N, Hirano T]
通讯作者： Hirano T
Comparative study of the effects of betamethasone butyrate propionate, vitamin D3 derivatives, and cyclosporine on human lymphocyte-proliferation stimulated with a hemolytic streptococci-derived superantigen
DOI： 10.1016/j.ejphar.2007.06.023
发表时间： 2007-10-01
期刊： EUROPEAN JOURNAL OF PHARMACOLOGY
影响因子： 5
作者： [Arai, Kae, Uchiyama, Terumi, Hirano, Toshihiko]
通讯作者： Hirano, Toshihiko
Clinical significance of cellular pharmacodynamics of tacrolimus in living-donor liver transplantation.
他克莫司细胞药效学在活体肝移植中的临床意义。
DOI： --
发表时间： 2009
期刊： Cell Transplantation 18
影响因子： --
作者： [Mijiti A, Matsuno N, Takeuchi H, Unezaki S, Nagao T, Hirano T]
通讯作者： Hirano T
腎移植患者がステロイドを安全に減量・離脱するための薬力学的指標の検討
肾移植患者安全减量和停药的药效学指标检查
DOI： --
发表时间： 2009
期刊：
影响因子： --
作者： [谷口雅彦, 竹内裕紀, 畝崎榮, 虎石竜典, 奥山清, 明石貴雄, 松野直徒, 木原優, 今野理, 城島嘉麿, 平良眞一郎, 濱耕一郎, 中村有紀, 岩本整, 葦沢龍人, 長尾桓, 平野俊彦]
通讯作者： 平野俊彦
共 22 条
    Effects of several antibiotics on proliferation and regulatory T cell frequency in human lymphocytes stimulated with superantigen
    Relationship between sensitivities of peripheral blood-mononuclear cells to immunosuppressive drugs and Staphylococcus aureus infection
    Influence of serum lipids on lymphocyte sensitivity to immunosuppressive drugs and its clinical implication in patients with nephrosis.
    Study on individual immunosuppressive therapy based on peripheral-blood lymphocyte-sensitivity to immunosuppressive drugs and the mechanisms on drug resistance
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