Establishment of personalized therapy with epidermal growth factor receptor inhibitors for lung cancer based on the inhibitory effects of surfactant secretion

基于表面活性物质分泌抑制作用建立表皮生长因子受体抑制剂肺癌个体化治疗

• 批准号: 19590901
• 负责人: SODA Hiroshi
• 金额: $ 2.91万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590901/
• 关键词: 肺癌; 分子標的治療; 個別化治療; 上皮成長因子受容体阻害; 肺サーファクタント蛋白; 上皮成長因子受容体阻害薬

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have dramatic effects in selective patients with non-small cell lung cancer. A non-invasive method for predicting the efficacy of EGFR tyrosine kinase inhbitors is needed in clinical settings. The production of surfactant proteins is reported to be regulated through the EGF signaling pathway. The present study suggested that EGFR mutations in the tumor and high levels of serum surfactant protein-D before treatment may predict the efficacy of EGFR tyrosine kinase inhibitors.

表皮生长因子受体（EGFR）酪氨酸激酶抑制剂对选择性非小细胞肺癌患者有显著作用。临床需要一种非侵入性的方法来预测EGFR酪氨酸激酶抑制剂的疗效。据报道，表面活性剂蛋白的产生是通过EGF信号通路调节的。目前的研究表明，肿瘤中的EGFR突变和治疗前血清表面活性蛋白- d的高水平可能预测EGFR酪氨酸激酶抑制剂的疗效。

项目成果

Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event

• DOI: 10.1016/j.lungcan.2009.10.007
• 发表时间: 2010-02-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Ide, Shotaro;Soda, Hiroshi;Kohno, Shigeru
• 通讯作者: Kohno, Shigeru

Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule

• DOI: 10.1016/j.lungcan.2007.08.021
• 发表时间: 2008-04-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Nakano, Hirofumi;Soda, Hiroshi;Kohno, Shigeru
• 通讯作者: Kohno, Shigeru

Methylation status of breast cancer resistance protein detected by methylation-specific PCR is inversely correlated with its expression in drug-resistant lung cancer cells.

甲基化特异性PCR检测的乳腺癌耐药蛋白的甲基化状态与其在耐药肺癌细胞中的表达呈负相关。

• 发表时间: 2008
• 期刊: Cancer 112
• 作者: 保嶋実;蔦谷昭司;Ueda K;Nakano H
• 通讯作者: Nakano H

Pharmacokinetics of gefitinib predicts the antitumor activity for advanced non- small cell lung cancer

吉非替尼的药代动力学预测晚期非小细胞肺癌的抗肿瘤活性

• 发表时间: 2007
• 作者: Fukuda M;Nakamura Y;Sano K;et.al.
• 通讯作者: et.al.

Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity

• DOI: 10.1016/j.lungcan.2008.12.020
• 发表时间: 2009-07-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Nakamura, Yoichi;Noguchi, Yuji;Kohno, Shigeru
• 通讯作者: Kohno, Shigeru