Mutations in genes encoding the K_<ATP> channel and their influence on efficacy of insulinotropic agents.

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Kir6.2, together with SUR1, forms an ATP-sensitive potassium (K_<ATP>) channel that plays a key role in insulin secretion from pancreatic ss-cells. In this study, we carried out functional analyses including electrophysiological analysis, and found significant differences in ATP-sensitivity, sulfonylurea-sensitivity, and membrane surface expression among the mutants. Furthermore, it is possible to evaluate the potential efficacy of these insulinotropic agents in patients with the mutation by using in vitro analyses.