Epigenetic mechanism underlying olfactory learning in young animal

在睁开眼睛之前断奶的幼鼠依靠体感和嗅觉功能生存，因为它们可以在没有视觉信息的情况下学习它们的气味并接近它们。为了建立嗅觉学习，气味和体感刺激的搭配是至关重要的。我们之前已经证明，OB区的突触可塑性是厌恶嗅觉学习的基础。特别是作为细胞机制，染色质结构在长期记忆形成的早期阶段通过组蛋白乙酰化的修饰而重塑。行为药理学表明，HDAC抑制巩固了幼年大鼠的厌恶嗅觉学习。

Preweanling young rats prior to eye opening depend on somatosensory and olfactory function for survival, as they can learn their dam's odor and approach her without visual information. In order to establish olfactory learning, the pairing of odor and somatosensory stimulation is crucial. We have previously shown that synaptic plasticity in the OB underlies aversive olfactory learning. Particularly as cellular mechanisms, chromatin structure is remodeled by modification of histone acetylation during the early stages of long-term memory formation. Behavioral pharmacology shows that HDAC inhibition consolidates aversive olfactory learning in young rats.