Strategy for neonatal chronic lung disease : Prevention from lung fibrosis with NO inhalation

新生儿慢性肺病策略：吸入一氧化氮预防肺纤维化

• 批准号: 19591286
• 负责人: OKUTANI Takahiro
• 金额: $ 2.83万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591286/
• 关键词: 新生児慢性肺疾患; 一酸化窒素吸入療法; 肺線維化

In infants with very low birth weight, the plasma angiotensin II levels gradually increased and reached a peak on day 21 thereafter decreased. Chronic lung disease was confirmed to be the most significant factor associated with the plasma angiotensin II levels on days 21 and 35. The plasma VEGF levels also increased gradually. In infants with chronic lung disease, the plasma VEGF levels tend to be higher than those in infants without chronic lung disease, but the difference was not statistically significant.

极低出生体重儿血浆血管紧张素II水平逐渐升高，第21天达高峰，之后下降。在第21天和第35天，慢性肺部疾病被确认为与血浆血管紧张素II水平相关的最显著因素。血浆血管内皮细胞生长因子水平也逐渐升高。慢性肺病患儿血浆血管内皮生长因子水平较非慢性肺病患儿高，但差异无统计学意义。

项目成果

The plasma angiotensin II level increases in very low-birth weight infants with neonatal chronic lung disease.

患有新生儿慢性肺病的极低出生体重婴儿的血浆血管紧张素 II 水平升高。

• 发表时间: 2008
• 期刊: Early Human Development 84
• 作者: Masakazu Miyawaki;Takahiro Okutani;Ryuzo Higuchi;Norishige Yoshikawa.
• 通讯作者: Norishige Yoshikawa.