Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis
Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis
批准号:
19591297
负责人:
YOKOZEKI Hiroo
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
我们建立了以STAT6为靶点的基因治疗。我们通过使用模型小鼠证明,用siRNA对STAT6进行基因沉默可以改善接触性超敏反应和变应性鼻炎。
英文摘要
We established the gene therapy targeting for STAT6. We demonstrated that gene siliencing of STAT6 with siRNA ameliorates both contact hypersensitivity and allergic rhinitis by using model mouse.
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Basophils involved in cutaneous allergic responses, detected by newly established mAbbs specific to basophil granular enzymes mMCP-8 and mMCP-11
嗜碱性粒细胞参与皮肤过敏反应,通过新建立的针对嗜碱性粒细胞颗粒酶 mMCP-8 和 mMCP-11 的 mAbb 进行检测
DOI:
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发表时间:
2008
期刊:
影响因子:
--
作者:
[Ugajin T, Kojima T, Obata K, Tsujimura Y, Mukai K, Kawano Y Satoh T, Minegishi Y, Yokozeki H, Karasuyama H]
通讯作者:
Karasuyama H
A therapeutic effect of STAT6 decoy oligodeoxynuckeoties ointment in atopic dermatitis
STAT6诱饵寡脱氧核酸软膏治疗特应性皮炎的疗效观察
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[Igawa K, Yahara H, Kanai Y, Sumi K, Satoh T, Nishioka K, Yokozeki H]
通讯作者:
Yokozeki H
蕁麻疹 ガイドライン:外来診療2007
荨麻疹指南:门诊治疗 2007
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Igawa K, Yahara H, Kanai Y, Sumi K, Satoh T, Nishioka K, Yokozeki H, 横関博雄, 横関博雄]
通讯作者:
横関博雄
Treatment of the allergic cutaneous inflammation in mouse model by STAT6 inhibition with RNA
RNA抑制STAT6治疗小鼠过敏性皮肤炎症模型
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Hosoya K, Igawa K, Satoh T, Yokozeki H]
通讯作者:
Yokozeki H
A therapeutic effect of STAT6 decoy oligodeoxynucleotides ointment in atopic dermatitis 5th Georg Rajka International Symposium on Atopic Dermatitis
STAT6诱饵寡脱氧核苷酸软膏治疗特应性皮炎第五届Georg Rajka国际特应性皮炎研讨会
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Igawa K, Satoh T, Yokozeki H]
通讯作者:
Yokozeki H
共 39 条
Analysis and development of a pinpointed and novel treatment focused on basophils for untreated skin allergic diseases
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批准号:16K10124
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2016
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负责人:YOKOZEKI Hiroo
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依托单位:
Analysis for the mechanism of prurigo reaction focusing on basophils
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批准号:22591218
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2010
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负责人:YOKOZEKI Hiroo
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依托单位:
A trial of gene therapy for contact allergy and atopic dermatitis
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批准号:13670869
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2001
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负责人:YOKOZEKI Hiroo
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依托单位:
Analysis of the role of STAT6 signaling in the induction of CHS
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批准号:10670781
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1998
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负责人:YOKOZEKI Hiroo
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依托单位:
Induction of tolerance of contact hypersensitivity by blocking CD28 Signal
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批准号:08670952
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1996
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负责人:YOKOZEKI Hiroo
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依托单位:
Molleculor Biological Analysis of the role of B71BB1 in contact dermatitis
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批准号:06670855
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1994
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负责人:YOKOZEKI Hiroo
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依托单位: