Analysis for the mechanism of prurigo reaction focusing on basophils

瘙痒症是一种常见病，以荨麻疹样丘疹和小结节为特征，伴有严重瘙痒。虽然Th 2型免疫与其病因有关，但其病理机制仍不清楚，我们最近的研究表明，在Alpigo病变中存在大量嗜碱性粒细胞。本研究表明，重复皮内注射TNP-OVA到背部皮肤病变。在组织学上，显著角化过度伴不规则棘皮病伴有致密浸润，包括单核细胞、嗜酸性粒细胞和肥大细胞数量增加。

Prurigo is a common disease characterized by urtical papules and bodules with severe itching. The pathological mechanism causing prurigo remains unclear, although Th2-type immunity has been implicated in its etiology and our recent study showed a number of basophils in prurigo lesion. The present study demonstrated that repeated intra-dermal injection of TNP-OVA to dosal skin lesions. Histologicallly, marked hyperkeratosis with irregular acanthosis was accompanied by dense infiltrate comprising mononuclear cells, eoshinophils, and increased number of mast cells.