Ability of elderly drivers to respond risky driving situations : Using near-infrared spectroscopy

老年驾驶员应对危险驾驶情况的能力：使用近红外光谱

• 批准号: 19591374
• 负责人: MIMURA Masaru
• 金额: $ 2.5万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591374/
• 关键词: 神経科学; 脳・神経; 老化; 自動車運転; 光トポグラフィ; 認知症; 高次脳機能障害; 注意; 認知科学; driving; Alzheimer's disease; mild cognitive impairment; near infra-red spectroscopy; simulator; risk; frontal lobe; visuospatial function

It is important to appropriately evaluate the driving performance of elderly persons. Near-infrared spectroscopy (NIRS) was employed to investigate differences of brain function between individuals with Alzheimer's disease and healthy elderly controls while they were being tested using a driving simulator. Changes of the oxyhemoglobin level in the prefrontal areas of each subject were measured by NIRS during a driving task (collision avoidance). Compared with healthy controls, the Alzheimer's disease group showed a less prominent increase of oxyhemoglobin in the prefrontal cortex during the collision avoidance task. The correlation between delay in braking and changes of oxyhemoglobin was positive in the healthy controls and negative in the Alzheimer's disease group, suggesting that a task-related prefrontal increase of oxyhemoglobin has different implications under normal and pathological conditions. NIRS is a potentially useful tool for real-time monitoring of prefrontal activity during simulated or actual driving.

对老年人的驾驶性能进行适当的评价是十分重要的。近红外光谱（NIRS）研究了阿尔茨海默病患者和健康老年人在驾驶模拟器上的脑功能差异。在驾驶任务（避碰）中，用近红外光谱测量了每个受试者前额叶区域的血红蛋白水平变化。与健康对照组相比，阿尔茨海默病组在避免碰撞任务期间前额叶皮层的血红蛋白增加不太明显。制动延迟与血红蛋白变化之间的相关性在健康对照组为正相关，而在阿尔茨海默病组为负相关，这表明任务相关的前额叶血红蛋白增加在正常和病理条件下具有不同的含义。近红外光谱是一种潜在的有用工具，可以实时监测模拟或实际驾驶期间的前额叶活动。

项目成果

Validation of the 7-Minute Screen for the detection of early-stage Alzheimer's disease

• DOI: 10.1159/000115972
• 发表时间: 2008-01-01
• 期刊: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
• 影响因子: 2.4
• 作者: Ijuin, Mutsuo;Homma, Akira;Gondo, Yasuyuki
• 通讯作者: Gondo, Yasuyuki

「認知症」は高次脳機能障害に含まれるのでしょうか.

“痴呆症”是否属于高级脑功能障碍？

• 发表时间: 2010
• 期刊: Modern Physician 30(1)
• 作者: 吉岡玲; 山本亜弥;森俊雄;中村祐;森川将行;芳野浩樹;木内邦明;牧之段学;岸本年史;吉岡 玲;森川将行;森俊雄;森 俊雄;三村將
• 通讯作者: 三村將

軽度認知障害への対応・訓練:説明と病名告知を含めて

轻度认知障碍的应对和培训：包括解释和疾病名称通知

• 发表时间: 2009
• 期刊: 老年精神医学雑誌 20
• 作者: 三村將;古田伸夫
• 通讯作者: 古田伸夫

Cognitive rehabilitation and cognitive training for mild dementia.

轻度痴呆的认知康复和认知训练。

• 发表时间: 2007
• 期刊: Psychogeriatrics 7
• 作者: Mimura M;Komatsu S
• 通讯作者: Komatsu S

Gender differences in lateralization of mismatch negativity in dichotic listening tasks

• DOI: 10.1016/j.ijpsycho.2008.01.006
• 发表时间: 2008-04-01
• 期刊: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
• 影响因子: 3
• 作者: Ikezawa, Satoru;Nakagome, Kazuyuki;Kamijima, Kunitoshi
• 通讯作者: Kamijima, Kunitoshi