Treatment for primary lung graft dysfunction by transfusion of endothelial progenitor cells transferred with intreleukin-10 gene.

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The purpose of this research project was to examine whether regeneration of pulmonary vascular endothelial cells that are derived from recipient cells can be observed in the rat lung in a rat model of lung transplantation, and whether transplantation of endothelial progenitor cells derived from bone marrow can facilitate regeneration of pulmonary endothelial cells. We performed rat lung transplantation from the SD rat donor to the GFPtg SD rat recipient and observed GFP(+), CD31(+) cell in the lung isograft, suggesting regeneration of endothelial cells derived from recipient cells occurs. We are planning recipient bone marrow cell transplantation to examine whether it can facilitate regeneration of pulmonary endothelial cells and also reduce ischemia-reperfusion injury of the lung isograft.