Elucidation of physiological roles of sphingosine 1-phosphate and its receptors in adipose tissue
Elucidation of physiological roles of sphingosine 1-phosphate and its receptors in adipose tissue
批准号:
19790650
负责人:
HASHIMOTO Takeshi
金额:
$2.35万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
前駆脂肪細胞が脂肪細胞へ分化する過程で、S1P産生酵素(SphK)のmRNAおよび蛋白質が著名に増加し、発現上昇したSphKが細胞内S1Pの生成を増加させる。SphK-1遺伝子をノックダウンした細胞は脂肪細胞への分化が抑制し、aP2・PPARγ・C/EBPαなどの転写因子のmRNAの発現は減少する。ob/obマウスの皮下脂肪組織においてSphK-1 mRNAの著名な発現上昇が認められ、マウス胎児から単離した初代培養細胞においても脂肪細胞への分化過程でSphK-1 mRNAは上昇することから、脂肪細胞の分化に対してSphK-1が重要な役割を果たしている可能性が示唆された。
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3T3-L1前駆脂肪細胞におけるSphingosine Kinase-1の脂肪細胞分化への関与
鞘氨醇激酶 1 参与 3T3-L1 前脂肪细胞的脂肪细胞分化
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[藤倉純二, 細田公則, 川口義弥, 野口倫生, 岩倉浩, 冨田努, 小鳥真司, 森栄作, 泰江慎太郎, 石井崇子, 岡田定規, 日下部徹, 平田雅一, 海老原健, 益崎裕章, 谷垣健二, 矢部大介, 中尾一和, 橋本剛;五十嵐淳介;小坂博昭]
通讯作者:
橋本剛;五十嵐淳介;小坂博昭
Sphingosine Kinase-1, an S1P-producing enzyme, promotes adipogenesis
Sphingosine Kinase-1 是一种 S1P 生成酶,可促进脂肪生成
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[藤倉純二, 細田公則, 川口義弥, 野口倫生, 岩倉浩, 冨田努, 小鳥真司, 森栄作, 泰江慎太郎, 石井崇子, 岡田定規, 目下部徹, 平田雅一, 海老原健, 益崎裕章, 谷垣健二, 矢部大介, 中尾一和, 橋本剛;五十嵐淳介;小坂博昭]
通讯作者:
橋本剛;五十嵐淳介;小坂博昭
Sphingosine Kinase 1,an SIP producing enzyme,promotes adipogenesis
鞘氨醇激酶 1,一种 SIP 产生酶,促进脂肪生成
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[橋本剛, 五十嵐淳介, 小坂博昭]
通讯作者:
小坂博昭
DOI:
10.1194/jlr.m800206-jlr200
发表时间:
2009-04-01
期刊:
JOURNAL OF LIPID RESEARCH
影响因子:
6.5
作者:
[Hashimoto, Takeshi, Igarashi, Junsuke, Kosaka, Hiroaki]
通讯作者:
Kosaka, Hiroaki
Prediction detection of the landslide disaster as an application of three-dimensional high-precision measurement technique
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Mifepristone improved Diet-induced insulin resistance by increasing blood level of adiponectin.
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The paradoxical efect of the norm of reciprocity on help-seeking
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Application of spectroscopy in remote sensing of volcanic gases
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High Precision 3D measurement system for Naturalistic observation
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The effects of exercise-inducible factors on lipid metabolism in adipocytes
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Sophistication of remote sensing in volcanic gas measurements
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Cultural influence on interpersonal stress process
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Production of high-precision position measurement system at long-distance and its applications on observation of natural phenomena
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Elucidation of contributing factors affecting the ζ-potential of volcanic rocks
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依托单位:
Expression of candidate susceptibility gene in the cingulated cortex of brains from patients with schizophrenia : a postmortem study
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依托单位:
Research on the intellectual control of the plural mobile robots using image measurement methods and its application
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依托单位:
Identification of novel candidate genes for schizophrenia: using postmortem brain study
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A Research on Autonomous Vehicle Navigation using Vision System
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负责人:HASHIMOTO Takeshi
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依托单位:
海外基金