The effects of exercise-inducible factors on lipid metabolism in adipocytes
The effects of exercise-inducible factors on lipid metabolism in adipocytes
批准号:
22700652
负责人:
HASHIMOTO Takeshi
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
The study investigated the cellular origin and physiological significance of micro lipid droplets (mLDs) that emerge in the cytoplasm during active lipolysis, as well as the roles of key liplolytic proteins on mLDs in differentiated 3T3-L1 adipocytes. The results suggest that, besides the surface of pre-existing central LDs, LD-associated proteins are actively involved in lipolysis on mLDs that are formed by fatty acids re-esterification. Furthermore, the lipolytic activity was increased by exercise-inducible factors such as H2O2, lactate-inducible signals, increased cellular calcium levels, AMP kinase, and nitric oxide inaccordance with elevated levels of LD-associated proteins and mitochondrial biogenic signaling.
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DOI:
10.7600/jpfsm.2.149
发表时间:
2013-05
期刊:
The Journal of Physical Fitness and Sports Medicine
影响因子:
--
作者:
[T. Hashimoto]
通讯作者:
T. Hashimoto
InVivoandinvitroanalysesofexercise-induciblefactorstoactivatelipolysisinadipocytes
激活脂肪细胞脂肪分解的运动诱导因子的体内和体外分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Hashimoto T, Osumi T, HashimotoT,EndoY,OkumuraM,SatoK,IemitsuM, HashimotoT,SatoK,IemitsuM]
通讯作者:
HashimotoT,SatoK,IemitsuM
スポーツサイエンス入門第2章スポーツにおけるエネルギーを生み出す仕組み
运动科学概论第二章运动中产生能量的机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[戸ヶ里泰典, 山崎喜比古, 中山和弘, 石田浩, 橋本健志]
通讯作者:
橋本健志
Controloflipolysisbylipiddroplet-associatedproteinsin3T3-L1adipocytes
3T3-L1 脂肪细胞中脂滴相关蛋白控制脂肪分解
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Hayashi K, Honda Y, Miyakawa N, Fujii N, Ichinose M, Koga S, Kondo N, Nishiyasu T, 伊藤望,市川陽子,鈴木裕一,林恵嗣, HashimotoT,EndoY,SatoK,IemitsuM]
通讯作者:
HashimotoT,EndoY,SatoK,IemitsuM
Dynamicbehaviorsoflipiddropletsandlipiddroplet-associatedproteinsduringstimulatedlipolysisinadipocytes-Functionalimplications
脂肪细胞刺激脂肪分解过程中脂滴和脂滴相关蛋白的动态行为-功能意义
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Hashimoto T, Osumi T, HashimotoT,EndoY,OkumuraM,SatoK,IemitsuM, HashimotoT,SatoK,IemitsuM, HashimotoT]
通讯作者:
HashimotoT
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