Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heart

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We performed experimental research to explore the roles of S1P and related molecules in ischemic heart diseases. It has been established that sphingolipid-enriched micro-compartments of peripheral plasma membrane termed caveolae and their structural component protein caveolin-1 play key roles in mediating S1P signaling. We determined that a cytokine TGFβ1 promotes S1P signaling in cultured vascular endothelial cells by attenuating caveolin-1 expression. We also discovered that steroid hormones are capable of up-regulating caveolin-1 to down-regulated VEGF receptor signaling pathways.