Aquaporin as a target of a new therapy for brain edema

膜孔蛋白，水通道蛋白（AQP），促进水和在某些情况下，小溶质的渗透驱动通过。AQPs在维持脑内环境稳定中起重要作用。在本研究中，我们观察到培养的大鼠星形胶质细胞中AQP 4的表达通过p38 MAPK或NF-kB而增加。此外，p38 MAPK抑制剂，而不是ERK和JNK抑制剂，和NF-kB抑制剂抑制培养的星形胶质细胞中AQP 4的表达。NF-kB抑制剂和p38 MAPK抑制剂可保护星形胶质细胞免受缺氧损伤。

The membrane pore proteins, aquaporins (AQPs), facilitate the osmotically driven passage of water and, in some instances, small solutes. AQPs play important roles in maintaining brain homeostasis. In this study, we observed that the expression of AQP4 was increased in cultured rat astrocytes through p38 MAPK or NF-kB, In addition, a p38 MAPK inhibitor, but not ERK and JNK inhibitors, and NF-kB inhibitors suppressed their expression in cultured astrocytes. NF-kB inhibitors and p38 MAPK inhibitor may protect astrocytes form the hypoxia-induced injury.