Development of Asymmetric Supramolecular Catalysts with Antibodies and Transition Metal Complexes

抗体和过渡金属配合物不对称超分子催化剂的开发

• 批准号: 19685010
• 负责人: YAMAGUCHI Hiroyasu
• 金额: $ 11.07万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19685010/
• 关键词: モノクローナル抗体; 遷移金属錯体; 超分子; 立体選択性; 不斉触媒; エネルギー変換; 触媒; 抗原抗体反応; 光学活性; 不斉認識; 不斉反応

Some monoclonal antibodies which can bind organic metal complexes with high specificity and high affinity were prepared in order to construct a specific reaction field utilizing their antigen-binding sites. Unique functions were developed by the incorporation of metal complexes into the binding site of monoclonal antibodies. Monoclonal antibodies for stereoisomers of transition metal complexes or enantiomers of organic compounds were also prepared successfully.

为了利用其抗原结合位点构建特异性反应场，制备了一些能与有机金属配合物高特异性、高亲和力结合的单克隆抗体。通过将金属络合物掺入单克隆抗体的结合位点来开发独特的功能。还成功地制备了过渡金属配合物立体异构体或有机化合物对映体的单克隆抗体。

项目成果

Monoclonal Antibodies with Specific Binding Affinity for Binaphthyl Enantiomers"

对联萘对映体具有特异性结合亲和力的单克隆抗体"

• 发表时间: 2009
• 作者: Odaka;T.
• 通讯作者: T.

Photoinduced Electron Transfer by the Supramolecular Complex Formation of Porphyrin with Cyclodextrin Bearing Viologen

卟啉与带有紫精的环糊精形成超分子复合物的光诱导电子转移

• 发表时间: 2008
• 作者: Takeda;Y.
• 通讯作者: Y.

高分子添加による水溶性イリジウム錯体の発光増大

通过添加聚合物增强水溶性铱配合物的发光

• 发表时间: 2008
• 作者: N.Kawaguchi;T.Yanagida;Y.Futami;K.Fukuda;T.Suyama;Y.Yokota;A.Yoshikawa;小西 孝治
• 通讯作者: 小西 孝治

Construction of Chemical-Responsive Supramolecular Hydrogels from guest-Modified Cyclodixtrins

客体改性环糊精构建化学响应性超分子水凝胶

• 发表时间: 2008
• 期刊: Chem. ASian J. in press
• 作者: Deng;W.
• 通讯作者: W.

Switching of polymerization activity of cinnamoyl-alpha-cyclodextrin.

• DOI: 10.1039/b818241h
• 发表时间: 2009-04
• 期刊: Organic & biomolecular chemistry
• 影响因子: 3.2
• 作者: Motofumi Osaki;Y. Takashima;H. Yamaguchi;A. Harada