Development of Novel Catalysts Utilizing Monoclonal Antibodies Specific for Optically Active Compounds with Thermoresponsive Particles

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Monoclonal antibodies are considered to be one of the suitable proteins which can be used as a tailor-made chiral recognition reagent. In this study, a chiral binaphthyl derivative waschosen as a target molecule (hapten) which is a precursor for 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP), a widely used ligand in asymmetric metal-catalyzed reactions. Wedemonstrated that one of the monoclonal antibodies elicited against the binaphthyl derivative coulddifferentiate one of the enantiomers. We could clearly visualize chiral recognition events of the antibody by using poly-N-isopropylacrylamide (pNIPAM) bearing the chiral binaphthyl derivative.