Development of basic technologies for the practical production and particulate design of pharmaceutical organic nanoparticles by the rapid expansion of supercritical solutions (RESS) technique

测定了4种药用有机化合物在超临界二氧化碳中的溶解度和11种二氧化碳+药用有机化合物体系的固液气三相平衡，这对理解和设计超临界溶液快速膨胀（RESS）技术具有重要意义。采用RESS技术制备了RS-（±）-布洛芬、乙酰水杨酸和茶碱的粒径分布较窄的纳米球形颗粒（约200 nm）。研究发现，通过RESS技术制备的纳米颗粒的性质受过饱和控制，过饱和定义为制备饱和溶质超临界溶液时溶质化学势与制备的颗粒收集时溶质化学势的差。

The solubility of four pharmaceutical organic compounds in supercritical carbon dioxide and the solid-liquid-gas three-phase equilibria for eleven carbon dioxide + pharmaceutical organic compound systems, which are very important to understand and design the rapid expansion of supercritical solutions (RESS) technique, were measured. The nano-sized spherical particles (dav ≈ 200 nm) with the narrow particle size distribution of RS-(±)-ibuprofen, acetylsalicylic acid and theophylline were produced by the RESS technique. The properties of the nanoparticles produced by the RESS technique were found to be controlled by the supersaturation defined as the difference between the chemical potential of the solute at the section of preparing the supercritical solution saturated with the solute and that at the section of the collection of the produced particles.