Development of basic research for practical application of particle design technique of drugs using the rapid expansion of supercritical solutions (RESS) technique

测定了Rs-（±）-布洛芬、咖啡因和茶碱在超临界CO2中的高可靠性溶解度，这对理解和设计超临界溶液快速膨胀（RESS）技术具有重要意义。本文提出的RESS技术制备药物纳米粒的装置和纳米粒设计技术具有很高的通用性，可用于茶碱、咖啡因、香草醛和（-）-冰片等药物的制备。此外，控制膨胀喷嘴温度对控制RESS技术制备药物的晶型也很重要。

High-reliability solubility of Rs-(±)-ibuprofen, caffeine and theophylline in supercritical carbon dioxide, which is very important to understand and design the rapid expansion of supercritical solutions (RESS) technique, was measured. The versatility of nanoparticle production apparatus and nanoparticle design technique ofdrugs using the RESS technique proposed by the authors was very high because the apparatus and particle design technique could be applied to several dnlgs such as theophylline, caffeine, vanillin, and (-) -bomeol. Moreover, controlling the expansion nozzle temperatures was ofimportance to control the polymorph of the drugs using the RESS technique.