Changes in genes expression following traumatic brain injury

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The ratios of most apoptosis-related gene transcripts changed primarily at 6 and 12 h following traumatic brain injury (TBI). The altered expression ratio decreased significantly at 48 h after trauma. The dynamic changes in expression of apoptosis-related genes were closely paralleled by similar alterations in inflammation-related genes after trauma. The altered genes involved in TBI-induced apoptosis included interleukin 1 and tumor necrotic factor which immediately increased and reached the maximum levels at 3 h following the injury. These results suggested that TBI induced apoptosis relate to inflammation response after trauma.