Changes in genes expression following traumatic brain injury

创伤性脑损伤后基因表达的变化

• 批准号: 19689015
• 负责人: SHOJO Hideki
• 金额: $ 16.47万
• 依托单位: University of Yamanashi (2008-2009)Saga University (2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19689015/
• 关键词: 頭部外傷; 受傷応答メカニズム; アポトーシス; マイクロアレイ解析

The ratios of most apoptosis-related gene transcripts changed primarily at 6 and 12 h following traumatic brain injury (TBI). The altered expression ratio decreased significantly at 48 h after trauma. The dynamic changes in expression of apoptosis-related genes were closely paralleled by similar alterations in inflammation-related genes after trauma. The altered genes involved in TBI-induced apoptosis included interleukin 1 and tumor necrotic factor which immediately increased and reached the maximum levels at 3 h following the injury. These results suggested that TBI induced apoptosis relate to inflammation response after trauma.

大部分细胞凋亡相关基因转录本的比例在颅脑损伤后6h和12h变化较大。创伤后48h，改变的表达率明显下降。细胞凋亡相关基因表达的动态变化与创伤后炎症相关基因的类似变化密切相关。参与脑损伤诱导细胞凋亡的改变基因包括白介素1和肿瘤坏死因子，它们在伤后即刻升高，3h达到最高水平。这些结果提示，颅脑损伤诱导的细胞凋亡与创伤后的炎症反应有关。

项目成果

脳内異物による脳病態の解析.

脑内异物引起的脑病理分析。

• 发表时间: 2008
• 作者: 中尾賢一朗;猩々英紀;木林和彦
• 通讯作者: 木林和彦

脳挫傷により誘導されるアポトーシスの経時的解析

脑挫裂伤诱导细胞凋亡的时程分析

• 发表时间: 2007
• 作者: 猩々英紀;木林和彦
• 通讯作者: 木林和彦

Unexpected death due to intestinal obstruction by duplication cyst in an infant.

婴儿因重复囊肿肠梗阻而意外死亡。

• 发表时间: 2007
• 期刊: Forensic Science International 173
• 作者: Kibayashi K;Sumida T;Shojo H;Tokunaga O.
• 通讯作者: Tokunaga O.

Hyperthermia combined with ethanol administration induces c-fos expression in the central amygdaloid nucleus of the mouse brain. A possible mechanism of heatstroke under the influence of ethanol intake

• DOI: 10.1007/s00414-008-0278-7
• 发表时间: 2009-09-01
• 期刊: INTERNATIONAL JOURNAL OF LEGAL MEDICINE
• 影响因子: 2.1
• 作者: Kibayashi, Kazuhiko;Nakao, Ken-ichiro;Shojo, Hideki
• 通讯作者: Shojo, Hideki

Traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury: A target for therapeutic int ervention.

中度液体冲击损伤后创伤性脑损伤诱导大鼠大脑皮层细胞凋亡：治疗干预的目标。

• 发表时间: 2010
• 作者: Kimura A;Ishida Y;Hayashi T;Nosaka M;Kondo T;Shojo H
• 通讯作者: Shojo H