Remedy for spinal cord injury focused on stem cells and self-repairing

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Although reactive astrocytes form a glial scar and are considered a physical barrier to prevent axonal regeneration, we found that reactive astrocytes play a crucial role in wound healing and functional recovery after spinal cord injury. To examine their cellular property, we utilized cell sorter and isolated them from injured spinal cord. We confirmed their property as neural stem/progenitors in vitro but no neuronal contribution in vivo. The method of flow cytometric sorting for neural cells could be a powerful tool for neuroscience research.