Regulation of hematopoiesis and tumorigenesis by Bcl6 and AP-1 gene family.

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The proto-oncogene bcl-6 and c-fos are ubiquitously expressed in various tissues, and play important role for the differentiation, proliferation, apoptosis and oncogeneisis. In this study, I focused on the function of bcl-6 and c-fos for the hematologic cells, using transgenic and gene deficient mice.1.Function of Bcl-6 on erythroid differentiationBcl-6 detected in the TER119highCD71high subset of erythroblasts in the spleen of neonatal mice may be required to retain the erythroblasts in the cell proliferation stage.2.Function of Bcl-6 on dendritic cell differentiationBcl-6 deficient mice showed decreased umber of dendritic cells in spleen. Especially CD8+ subfraction of dendriti cells was completely deficient.3.Function of c-fos on B cell differentiationUsing H2-c-fos transgenic mice, we showed that c-Fos positively regulated blimp-1 expression and terminal differentiation of activated B cells.