A study for axon regeneration in the damaged CNS -clarification of inhibitory mechanisms of chondroitin sulfate proteoglycan

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I attempt to molecularly clarify why axons cannot regenerate in the damaged spinal cord where a gradient of chondroitin sulfate proteoglycan (CSPG) is formed. I used a culture system that reproduced axon endings failing to migrate forward on the inhibitory CSPG gradient. In this study, I conclude that regulation of cell-matrix adhesion formation plays a critical role in axon regeneration across the inhibitory CSPG gradient.