Determination of local stress and deformation in human skeletal muscles using a combined approach of in vivo experiments with computer simulation.

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Novel methods based on clinical MRI sequences (e.g. Spin tagging MRI, Phase contrast MRI and Diffusion tensor MRI) were established to investigate muscle information in detail such as local deformation and fiber arrangement. In addition, by usage of these experimental results as data of both input and model validation, a new finite element simulation model was successfully developed. This model has 3 dimensional fascicle arrangement and contractile dynamics of muscle fibers, and could compute deformation by internal force generated in muscle fibers during exercise. Non-uniformity of tissue strain, strain concentration, significance of aponeurosis, relation between mechanical properties of tendon and damage of tissues etc. were investigated.