Elucidating metastasis mechanisms and prognostic factors in neuroendocrine tumors

阐明神经内分泌肿瘤的转移机制和预后因素

• 批准号: 17K08713
• 负责人: 大久保 陽一郎
• 金额: $ 3万
• 依托单位: Kanagawa Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08713/
• 关键词: 神経内分泌腫瘍; 神経内分泌癌; neuroendocrine neoplasm; neuroendocrine carcinoma; CoGNET; neuroendocrine tumor; paraganglioma; カルチノイド

神経内分泌腫瘍は世界中で増加しているが、その悪性度を完全に評価する指標はまだ確立されていない。特に再発・転移メカニズムに関しては病理形態や分化度を考慮に入れると複雑化し、確実な予測因子については更なる調査が求められる。2022年度はgangliocytic paragangliomaの研究を進めた。本腫瘍は主に十二指腸から発生する稀な神経内分泌腫瘍であり、その形態学的特徴からparagangliomaと呼ばれてきた。しかし最近の分子病理学的解析により、本腫瘍は真のparagangliomaよりも消化管起源のneuroendocrine tumorの特性を有することが示された。研究代表者らは国際会議（Web会議）でこの議題を討論し、paragangliomaという名前が現在では適切でなく、形態学的特徴も考慮した新しい名称が適切であるとのコンセンサスに達した。結果、composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET)という名称が採用され、"WHO Classification of Tumours Editorial Board. Endocrine and Neuroendocrine tumours, 5th ed"にCoGNETとして報告した。さらに、膵臓・消化管由来の神経内分泌癌の症例収集、画像解析、他院標本の再評価などを進めてきた結果、他臓器のMRI画像解析所見と生検標本への影響度が明確になり、high volume centerにおける再評価の有用性を客観的な数値で検出することに成功した。そのため、CoGNETの発表に加えて、これらの知見も副次的な論文として公表した。

In the world of endocrinology, there is an increase in the level of sex, which means that it is necessary to make sure that it is correct. Please make sure that the factors are more sensitive to the differentiation of pathomorphology and morphology. The "gangliocytic paraganglioma" research in 2022 has been advanced. This master refers to the special characteristics of endocrinology, paraganglioma, and physiology. The recent molecular pathology analysis of paraganglioma, the origin of digestive tract and the characteristics of neuroendocrine tumor are shown in this paper. Research representatives have been invited to discuss topics at the International Conference (Web), the names of the special exams of physiognomy and physiology are now available before the names of the participants in the International Conference (International Conference). The results show that the name of the composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET) report is different from that of the WHO Classification of Tumours Editorial Board, "WHO Classification of Tumours Editorial Board, Endocrine and Neuroendocrine tumours, 5th ed", and the name of the report is different. The collection of cases of endocrine cancer, the analysis of portraits, the analysis of the results of other hospital signs, the analysis of the MRI portraits of other doctors, the accuracy of the images of the signs of endocrine cancer, the origin of digestive tract, the causes of endocrine cancer, the origin of digestive tract, the causes of endocrine cancer, the analysis of portraits of other hospitals, the analysis of MRI portraits, and the number of users of useful customers show that they are successful. In the second order of the public table, please add the information in the CoGNET table, and add the information in the table.

项目成果

Two cases of thyroid gland invasion by upper mediastinal carcinoma

上纵隔癌侵犯甲状腺二例

• DOI: 10.1530/edm-19-0028
• 发表时间: 2019
• 期刊: Endocrinology, Diabetes & Metabolism Case Reports
• 作者: Yamazaki Haruhiko;Iwasaki Hiroyuki;Okubo Yoichiro;Suganuma Nobuyasu;Masudo Katsuhiko;Nakayama Hirotaka;Rino Yasushi;Masuda Munetaka
• 通讯作者: Masuda Munetaka

Occult Thyroid Carcinoma without Malignant Thyroid Gland Findings during Preoperative Examination: Report of Three Cases

术前检查未发现甲状腺恶变的隐匿性甲状腺癌三例报告

• DOI: 10.1155/2020/4249067
• 发表时间: 2020
• 期刊: Case Reports in Endocrinology
• 影响因子: 1.1
• 作者: Toda Soji;Iwasaki Hiroyuki;Suganuma Nobuyasu;Okubo Yoichiro;Hayashi Hiroyuki;Masudo Katsuhiko;Nakayama Hirotaka;Masuda Munetaka
• 通讯作者: Masuda Munetaka

Clinicopathological and genetic analyses of small cell neuroendocrine carcinoma of the prostate: Histological features for accurate diagnosis and toward future novel therapies

• DOI: 10.1016/j.prp.2021.153731
• 发表时间: 2021-12-21
• 期刊: PATHOLOGY RESEARCH AND PRACTICE
• 影响因子: 2.8
• 作者: Ida，Arika;Okubo，Yoichiro;Miyagi，Yohei
• 通讯作者: Miyagi，Yohei

Risk factors associated with the progression and metastases of hindgut neuroendocrine tumors: a retrospective study.

• DOI: 10.1186/s12885-017-3769-4
• 发表时间: 2017-11-16
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Okubo Y;Kasajima R;Suzuki M;Miyagi Y;Motohashi O;Shiozawa M;Yoshioka E;Washimi K;Kawachi K;Kameda Y;Yokose T
• 通讯作者: Yokose T

WHO Classification of Tumours Editorial Board. Endocrine and Neuroendocrine tumours,5th ed (Composite gangliocytoma/neuroma and neuroendocrine tumour (CoGNET))

世界卫生组织肿瘤分类编辑委员会。

• 发表时间: 2022
• 作者: Guido Rindi ; Sylvia L. Asa ; Anthony J. Gill ; Talia L. Fuchs ; Silvia Uccella ; Yoichiro Okubo
• 通讯作者: Yoichiro Okubo