Gene expression profiles in endometrial carcinoma

应用基因表达序列分析(SAGE)技术对子宫内膜癌的基因表达谱进行了分析，实现了对大量转录本的同时定量分析。分析了22000多个来自正常子宫内膜组织和子宫内膜癌组织的转录本。虽然正常子宫内膜组织和子宫内膜癌组织的表达谱具有很大的相似性，但在分化型和未分化型子宫内膜癌中，许多转录本，如B因子备解素、尿苷磷酸化酶和细胞周期蛋白G1相互作用蛋白的表达水平非常不同。这些数据提供了新的信息，可能被用来识别对子宫内膜癌诊断和治疗有用的基因。

The gene expression profiles of human endometrial carcinoma were analysed by serial of gene expression (SAGE) which allows quantitative and simultaneous analysis of a large number of transcripts. More than 22000 transcripts deriverd from a normal endometrial tissue and endometrial carcinoma tissue were analysed. While extensive similarity was noted between the expression profiles of the normal endometrial tissue and endometrial carcinoma tissue, many transcripts, such as B-factor properdin, uridine phosphorylase, and cyclin G1 interacting protein, were expressed at extremely different levels in differentiated and undifferentiated carcinoma. These data provide new information that might be used to identify genes useful for the diagnosis and treatment of endometrial carcinoma.