Gene expression profiles in endometrial carcinoma

子宫内膜癌的基因表达谱

• 批准号: 19591939
• 负责人: NISHIKAWA Hiroshi
• 金额: $ 2.91万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591939/
• 关键词: 婦人科腫瘍学; 子宮体癌; 分子診断; プロファイル; 遺伝子

The gene expression profiles of human endometrial carcinoma were analysed by serial of gene expression (SAGE) which allows quantitative and simultaneous analysis of a large number of transcripts. More than 22000 transcripts deriverd from a normal endometrial tissue and endometrial carcinoma tissue were analysed. While extensive similarity was noted between the expression profiles of the normal endometrial tissue and endometrial carcinoma tissue, many transcripts, such as B-factor properdin, uridine phosphorylase, and cyclin G1 interacting protein, were expressed at extremely different levels in differentiated and undifferentiated carcinoma. These data provide new information that might be used to identify genes useful for the diagnosis and treatment of endometrial carcinoma.

应用SAGE技术对人子宫内膜癌的基因表达谱进行了分析。分析了来自正常子宫内膜组织和子宫内膜癌组织的22000多个转录本。虽然广泛的相似性之间的正常子宫内膜组织和子宫内膜癌组织的表达谱，许多成绩单，如B-因子备解素，尿苷磷酸化酶，细胞周期蛋白G1相互作用蛋白，表达在分化和未分化癌在极其不同的水平。这些数据提供了新的信息，可能被用来确定基因有用的诊断和治疗子宫内膜癌。