Studies on the mechanisms of regulation of catecholamine release in the nucleus accumbens

点击翻译按钮获取中文摘要

Oral dyskinesia is a neurological syndrome associated with aging or use of drugs for Parkinson's disease and antipsychotics. It is characterized by repetitive stereotyped oral movement The detaned biological basis of the disorder remains unclear, but the phamaco-behavioural studies suggest that enhance of dopamine function in the nucleus accumbens and striatum plays a pivotal role for the induction of repetitive jaw movements of rats. Therefore, in the present study, we nvestigated the mechanisms of increase in accumbal and striatal dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.