Studies on the mechanisms of regulation of catecholamine release in the nucleus accumbens

口腔运动障碍是一种与衰老或使用帕金森病药物和抗精神病药物相关的神经系统综合征。其特征是重复刻板的口腔运动。其生物学基础尚不清楚，但药理行为学研究表明，中脑核和纹状体多巴胺功能的增强在诱导大鼠重复性颌运动中起关键作用。因此，在本研究中，我们探讨了增加的机制，在自由活动的大鼠，在体内脑微透析技术。

Oral dyskinesia is a neurological syndrome associated with aging or use of drugs for Parkinson's disease and antipsychotics. It is characterized by repetitive stereotyped oral movement The detaned biological basis of the disorder remains unclear, but the phamaco-behavioural studies suggest that enhance of dopamine function in the nucleus accumbens and striatum plays a pivotal role for the induction of repetitive jaw movements of rats. Therefore, in the present study, we nvestigated the mechanisms of increase in accumbal and striatal dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.