The induction mechanism of new bone formation by sintered carbonate apatite grafted into bone

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The sintered carbonate apatite grafted into rat bone at one month after implantation was coated with fibroblast-like cells, osteoblast-like cells, and/or multi-nucleated giant cells. Although part of the sintered carbonate apatite was absorbed by multinucleated giant cells or macrophages, adjacent to the surface of the survived carbonate apatite, moderate electron dense layer of about 100nm in width, was observed, where newly formed bone was frequently formed. Small type of HID-TCH-SP stain deposits that represent sulfated glycoconjugates or sulfated glycoproteins were detected over the layer.