Development of new therapy of oral infection and cancer by applying innate immunity network.

我们研究了与天然免疫相关的多种宿主防御肽(HDPs)的抗菌和抗肿瘤作用。此外，我们还证实了在人类中发现的唯一的阳离子抗菌蛋白18(HCAP18)家族成员，它调节上皮细胞和鳞状细胞癌细胞的信号转导。结果表明，hCAP18与防御素和乳杆菌多肽具有协同杀菌作用。此外，我们还发现hCAP18编码的cAMP基因在人鳞状细胞癌中具有肿瘤抑制活性。

We studied the antimicrobial and antitumor effects of various host defense peptides (HDPs) associates with innate immunity. Additionally, we demonstrated the only member of the cathelicidin family identified in humans, as human cationic antimicrobial protein 18 (hCAP18) regulates signal transduction in epithelial cells and squamous cell carcinoma cells. Our results demonstrated that the bacterial killing of hCAP18 was synergistic with defensin and lactobacilluspeptide, as lactacin. In addition, we show that hCAP18 encoded CAMP gene is tumor suppressive activity in human squamous cell carcinoma.