Search for target molecule for immunotherapy based on Porphyromonas gingivalis genome analysis

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Porphyromonas gingivalis (P.gingivalis), an important periodontal pathogen in periodontitis, possesses a variety of virulent factors, and are classified into six genotypes (types I-V and Ib) based on the genotype of fimbriae A (fimA). The epidemiological studies shown that fimA II strains is harbored in most of the aggressive periodontal patients, and are thought to be strongest related to aggressive periodontitis, furthermore, fimA II is most frequently detected in patients with cardiovascular disease. In this report, to develop passive immunotherapy, we tryied to search the new pathogen of this type II P.gingivalis using the genomic and proteomic techniques, and then mouse monoclonal antibody (MAb), which neutralizes virulent factor activity, is constructed.