Elucidation of molecular pathogenesis and therapeutic targets for refractory hematological malignancies
Elucidation of molecular pathogenesis and therapeutic targets for refractory hematological malignancies
批准号:
19679004
负责人:
KUROKAWA Mineo
金额:
$64.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (S)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011
中文摘要
在这项研究中,我们证明了Evi-1转录的表观遗传调控对其白血病发生能力至关重要。我们还利用AML1条件敲除小鼠揭示了AML1功能丧失促进白血病发生的新的分子机制。此外,使用新生成的Evi-1条件敲除小鼠和Evi-1-ires- gfp敲入小鼠,我们证明了Evi-1与造血干细胞或白血病干细胞表型之间的独特关系。这些结果为开发新的分子靶向治疗难治性恶性血液病提供了基础。
英文摘要
In this study, we demonstrated that the epigenetic regulation of transcription by Evi-1 is essential for its leukemogenic capacity. We also revealed the novel molecular mechanisms by which the loss-of-function of AML1 promotes leukemogenesis, using our Aml1 conditional knockout mice. Furthermore, using newly generated Evi-1 conditional knockout mice and Evi-1-ires-GFP knock-in mice, we demonstrated a distinctive relationship between Evi-1 and the phenotype of hematopoietic stem cells or leukemic stem cells. These results provide a foundation to develop novel molecular targeted therapies for refractory hematological malignancies.
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DOI:
10.1016/j.bbmt.2010.07.010
发表时间:
2011-03-01
期刊:
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
影响因子:
4.3
作者:
[Kagoya, Yuki, Kataoka, Keisuke, Kurokawa, Mineo]
通讯作者:
Kurokawa, Mineo
DOI:
10.2174/187152709789541943
发表时间:
2009-11-01
期刊:
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
影响因子:
3
作者:
[Nagai, Sumimasa, Takahashi, Tsuyoshi, Kurokawa, Mineo]
通讯作者:
Kurokawa, Mineo
DOI:
10.1038/bmt.2010.48
发表时间:
2010-12-01
期刊:
BONE MARROW TRANSPLANTATION
影响因子:
4.8
作者:
[Ueda, K., Watadani, T., Kurokawa, M.]
通讯作者:
Kurokawa, M.
Nilotinib-induced hypothyroidism in a patient with chronic myeloid leukemia
慢性粒细胞白血病患者尼洛替尼诱发的甲状腺功能减退症
DOI:
10.1007/s12185-011-0790-2
发表时间:
2011
期刊:
International Journal of Hematology
影响因子:
2.1
作者:
[Yoshizato T, Nannya Y, Yoshiki Y, Nakamura F, Imai Y, Ichikawa M, Kurokawa M]
通讯作者:
Kurokawa M
Notch activation induces the generation of functional natural killer cells from human cord blood CD34-positive cells devoid of interleukin-151.
Notch 激活诱导不含 IL-151 的人脐带血 CD34 阳性细胞产生功能性自然杀伤细胞。
DOI:
--
发表时间:
2009
期刊:
The Journal of Immunology 15
影响因子:
--
作者:
[Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.]
通讯作者:
Chiba S.
共 103 条
Elucidation of mechanisms of myelodysplastic syndrome progression by RNAi screening.
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批准号:25670445
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:KUROKAWA Mineo
-
依托单位:
Pathophysiological elucidation of refractory leukemias with the genetic analyses at the single-cell level
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批准号:24659457
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
-
负责人:KUROKAWA Mineo
-
依托单位:
Comprehensive analysis of oncogenic transcriptional factor Evi-1.
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批准号:17390273
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.83万
-
财政年份:2005
-
负责人:KUROKAWA Mineo
-
依托单位:
Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210^<bcr/abl>
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批准号:11670981
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.62万
-
财政年份:1999
-
负责人:KUROKAWA Mineo
-
依托单位:
海外基金