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Elucidation of molecular pathogenesis and therapeutic targets for refractory hematological malignancies

Elucidation of molecular pathogenesis and therapeutic targets for refractory hematological malignancies
阐明难治性血液恶性肿瘤的分子发病机制和治疗靶点
批准号:
19679004
负责人:
KUROKAWA Mineo
金额:
$64.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (S)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011

项目摘要

项目成果

KUROKAWA Mineo的其他基金

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相关文献

中文摘要
翻译
在这项研究中,我们证明了Evi-1转录的表观遗传调控对其致白血病能力至关重要。我们还揭示了新的分子机制,通过这种机制,AML 1的功能丧失促进白血病发生,使用我们的AML 1条件性敲除小鼠。此外,使用新产生的Evi-1条件性敲除小鼠和Evi-1-ires-GFP敲入小鼠,我们证明了Evi-1和造血干细胞或白血病干细胞表型之间的独特关系。这些结果为难治性恶性血液病的分子靶向治疗提供了基础。
英文摘要
In this study, we demonstrated that the epigenetic regulation of transcription by Evi-1 is essential for its leukemogenic capacity. We also revealed the novel molecular mechanisms by which the loss-of-function of AML1 promotes leukemogenesis, using our Aml1 conditional knockout mice. Furthermore, using newly generated Evi-1 conditional knockout mice and Evi-1-ires-GFP knock-in mice, we demonstrated a distinctive relationship between Evi-1 and the phenotype of hematopoietic stem cells or leukemic stem cells. These results provide a foundation to develop novel molecular targeted therapies for refractory hematological malignancies.
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DOI: 10.1016/j.bbmt.2010.07.010
发表时间: 2011-03-01
期刊: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
影响因子: 4.3
作者: [Kagoya, Yuki, Kataoka, Keisuke, Kurokawa, Mineo]
通讯作者: Kurokawa, Mineo
DOI: 10.2174/187152709789541943
发表时间: 2009-11-01
期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
影响因子: 3
作者: [Nagai, Sumimasa, Takahashi, Tsuyoshi, Kurokawa, Mineo]
通讯作者: Kurokawa, Mineo
DOI: 10.1038/bmt.2010.48
发表时间: 2010-12-01
期刊: BONE MARROW TRANSPLANTATION
影响因子: 4.8
作者: [Ueda, K., Watadani, T., Kurokawa, M.]
通讯作者: Kurokawa, M.
The impact of molecularly targeted therapies upon the understanding of leukemogenesis and the role of hematopoietic stem cell transplantation in acute promyelocytic leukemia.
分子靶向治疗对理解白血病发生的影响以及造血干细胞移植在急性早幼粒细胞白血病中的作用。
DOI: --
发表时间: 2010
期刊: Current Stem Cell Research & Therapy
影响因子: 2.7
作者: [Nagai S, Takahashi T, Kurokawa M.]
通讯作者: Kurokawa M.
共 103 条
    Elucidation of mechanisms of myelodysplastic syndrome progression by RNAi screening.
    • 批准号:
      25670445
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      KUROKAWA Mineo
    • 依托单位:
    Pathophysiological elucidation of refractory leukemias with the genetic analyses at the single-cell level
    • 批准号:
      24659457
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2012
    • 负责人:
      KUROKAWA Mineo
    • 依托单位:
    Comprehensive analysis of oncogenic transcriptional factor Evi-1.
    • 批准号:
      17390273
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.83万
    • 财政年份:
      2005
    • 负责人:
      KUROKAWA Mineo
    • 依托单位:
    Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210^<bcr/abl>
    • 批准号:
      11670981
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.62万
    • 财政年份:
      1999
    • 负责人:
      KUROKAWA Mineo
    • 依托单位:
    海外基金