Pathophysiological elucidation of refractory leukemias with the genetic analyses at the single-cell level

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In this study, we assessed the variations of BCR-ABL expression at the single-cell level, with the use of patient samples from a t(3;21) positive chronic myeloid leukemia patient and a single-cell gene expression analyzer. We assessed several cell populations of patient samples, isolated via surface antigen profiles. In the result, we found that the expression level of BCR-ABL in CD34+/ CD38-/CD90+ leukemic cells was likely to be lower than those in other fractions at the single-cell level.