Gene expression noise during cell differentiation and its regulation
Gene expression noise during cell differentiation and its regulation
批准号:
20200006
负责人:
YAMAMOTO Takashi
金额:
$18.64万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In order to analyze the gene expression level during cell differentiation quantitatively, we established the reporter-knockin system into specific site of genome using engineered zinc-finger nucleases (ZFNs). Using this technology, we inserted reporter genes into target sites within the sea urchin Ets (HpEts) gene, which is expressed in presumptive primary mesenchyme cells (PMCs) and PMCs, and monitored the expression at one cell level during development, and found that gene expression noise increased during PMC differentiation in sea urchin development.
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Implication of HpEts in gene regulatory networks responsible for specification of sea urchin skeletogenic primary mesenchyme cells.
HpEts 在负责海胆成骨原代间充质细胞规范的基因调控网络中的意义。
DOI:
--
发表时间:
2010
期刊:
Zoological Science 27(8)
影响因子:
--
作者:
[Yajima M, Umeda R, Fuchikami T, Kataoka M, Sakamoto N, Yamamoto T, Akasaka K.]
通讯作者:
Akasaka K.
DOI:
10.1111/j.1440-169x.2008.01034.x
发表时间:
2008-06-01
期刊:
DEVELOPMENT GROWTH & DIFFERENTIATION
影响因子:
2.5
作者:
[Motoi, Natsuki, Suzuki, Ken-ichi, Yoshizato, Katsutoshi]
通讯作者:
Yoshizato, Katsutoshi
Mammalian arlysulfatase A functions as a novel component of the extracellular matrix.
哺乳动物芳基硫酸酯酶 A 作为细胞外基质的新成分发挥作用。
DOI:
--
发表时间:
2010
期刊:
Connective Tissue Research
影响因子:
2.9
作者:
[Nishikawa M, Shibata T., Ochiai H., Fujita K., Fujita K.]
通讯作者:
Fujita K.
Targeted manipulation of genes with zinc finger nucleases in the cricket, Gryllus bimaculatus
用锌指核酸酶对蟋蟀 Gryllus bimaculatus 中的基因进行靶向操作
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nishikawa M, Takagi H, Shibata T, Iwane AH, Yanagida T., Ochiai H., Motoi N., Shibata T., Ishihara S., Nishikawa M., Watanabe Takahito]
通讯作者:
Watanabe Takahito
Relationship between the noise in adaptation reaction and the chemotactic performance in bacterium
细菌适应反应噪声与趋化性能的关系
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nishikawa M, Takagi H, Shibata T, Iwane AH, Yanagida T., Ochiai H., Motoi N., Shibata T., Ishihara S., Nishikawa M., Watanabe Takahito, Watanabe T., Takebayashi-Suzuki Kimiko, 吉田隆也, 藤田和将, 西川正俊, Nishikawa Masatoshi, 藤田和将, 山本卓, 西川正俊, Nishikawa Masatoshi]
通讯作者:
Nishikawa Masatoshi
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Physiological analysis of SLC22A18 gene associated with visceral fat accumulation
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Development of universal method for genome modification using zinc finger nuclease
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Learning support by the E- Learning using a Cloud and Evaluation, Analysis of The Ripple Effect
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Comparative Study on Urban Poverty and Neighbourhood Governance inEngland and Japan
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Evaluation of ceramics grain blandly using AFM-Raman spectroscopy
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Study on the Formation of Administrative Documents System in Ancient Japan: Functional analyses on the mokkan before Taiho ritsuryo code and other related documents
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Palatability and koku of food-studies on their characteristics and measures how to control over-eating
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Quantitative analysis of cell-cell interaction responsible for the robustness of development
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