Physiological analysis of SLC22A18 gene associated with visceral fat accumulation

SLC22A18基因与内脏脂肪堆积相关的生理分析

• 批准号: 24790909
• 负责人: YAMAMOTO Takashi
• 金额: $ 2.75万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790909/
• 关键词: メタボリックシンドローム; 連鎖解析; 内臓脂肪; トランスポーター

In this study, to investigate the physiological functions of SLC22A18, an orphan transporter, in visceral fat accumulation and hepatic lipid accumulation, we analyzed SLC22A18-genetically modified mice and screened the endogenous substrate of SLC22A18. Animal experiments revealed that SLC22A18 positively regulates fat accumulation and triglyceride accumulation in liver. We found bilirubin as a candidate of SLC22A18 substrates. These results indicate the novel function of SLC22A18 and suggest the possibility of SLC22A18 as a therapeutic target of metabolic disorder.

为了研究SLC22A18（孤儿转运蛋白）在内脏脂肪蓄积和肝脏脂质蓄积中的生理功能，我们分析了SLC22A18基因修饰小鼠，并筛选了SLC22A18的内源性底物。 动物实验显示，SLC22A18正调节肝脏中的脂肪积累和甘油三酯积累。 我们发现胆红素作为SLC22A18底物的候选者。 这些结果表明了SLC22A18的新功能，并暗示了SLC22A18作为代谢紊乱的治疗靶点的可能性。

项目成果

A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat

• DOI: 10.1016/j.bbrc.2013.09.096
• 发表时间: 2013-11-01
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Yamamoto, Takashi;Izumi-Yamamoto, Kozue;Gotoda, Takanari
• 通讯作者: Gotoda, Takanari

Identification of SLC22A18 as a regulator of fat accumulation in the liver

鉴定 SLC22A18 作为肝脏脂肪积累的调节因子

• 发表时间: 2012
• 作者: Takashi Yamamoto;Midori Shirota;Yoko Iizuka;Toshiro Fujita;Takanari Gotoda
• 通讯作者: Takanari Gotoda