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Physiological analysis of SLC22A18 gene associated with visceral fat accumulation

Physiological analysis of SLC22A18 gene associated with visceral fat accumulation
SLC22A18基因与内脏脂肪堆积相关的生理分析
批准号:
24790909
负责人:
YAMAMOTO Takashi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
In this study, to investigate the physiological functions of SLC22A18, an orphan transporter, in visceral fat accumulation and hepatic lipid accumulation, we analyzed SLC22A18-genetically modified mice and screened the endogenous substrate of SLC22A18. Animal experiments revealed that SLC22A18 positively regulates fat accumulation and triglyceride accumulation in liver. We found bilirubin as a candidate of SLC22A18 substrates. These results indicate the novel function of SLC22A18 and suggest the possibility of SLC22A18 as a therapeutic target of metabolic disorder.
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Identification of SLC22A18 as a regulator of fat accumulation in the liver
鉴定 SLC22A18 作为肝脏脂肪积累的调节因子
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Takashi Yamamoto, Midori Shirota, Yoko Iizuka, Toshiro Fujita, Takanari Gotoda]
通讯作者: Takanari Gotoda
DOI: 10.1016/j.bbrc.2013.09.096
发表时间: 2013-11-01
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Yamamoto, Takashi, Izumi-Yamamoto, Kozue, Gotoda, Takanari]
通讯作者: Gotoda, Takanari
Development of structure-controlled early transition metal binary oxide based acid-base catalysts and the activity controlling factor
  • 批准号:
    19K05150
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.75万
  • 财政年份:
    2019
  • 负责人:
    YAMAMOTO Takashi
  • 依托单位:
Molecular activation and chemical conversion by dielectric property
  • 批准号:
    17K19180
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
  • 资助金额:
    $3.99万
  • 财政年份:
    2017
  • 负责人:
    YAMAMOTO Takashi
  • 依托单位:
Fundamental studies of "tyuusinngura"syokijitsuroku
  • 批准号:
    17K02477
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2017
  • 负责人:
    YAMAMOTO Takashi
  • 依托单位:
Examination of measures to support the management of corporate real estate using information about the fair values of investment properties
  • 批准号:
    15K03614
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2015
  • 负责人:
    YAMAMOTO Takashi
  • 依托单位:
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