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ex vivo gene manipulation of mesenchymal stem cell and application to cell therapy

ex vivo gene manipulation of mesenchymal stem cell and application to cell therapy
间充质干细胞的离体基因操作及其在细胞治疗中的应用
批准号:
20200013
负责人:
MAEDA Yasushi
金额:
$16.47万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Bone marrow derived mesenchymal stem cells (MSC) could be isolated and cultured from muscular dystrophy model mouse. And it was proved that gene manipulation by helper-dependent adenovirus of was possible without any tricky technique. Moreover, we found MSC’s novel competence to treat muscular dystrophy. MSC has intrinsic ability to modify muscle degeneration and regeneration. We found various growth factors are produced from MSC, and some growth factors of them give effects on muscle regeneration.
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会议论文
Dystrophim delivery to muscles of mdx mice using lentiviral vectors leads to myogenic progenitor targeting and stable gene expression
使用慢病毒载体将肌营养不良蛋白递送至 mdx 小鼠的肌肉,导致肌源性祖细胞靶向和稳定的基因表达
DOI: --
发表时间: 2010
期刊: Molecular Therapy
影响因子: 12.4
作者: [Raab, S.,…, Koshiba, T.,…他4名, Kimura E]
通讯作者: Kimura E
DOI: 10.1371/journal.pone.0016908
发表时间: 2011-03-18
期刊: PloS one
影响因子: 3.7
作者: [Suga T, Kimura E, Morioka Y, Ikawa M, Li S, Uchino K, Uchida Y, Yamashita S, Maeda Y, Chamberlain JS, Uchino M]
通讯作者: Uchino M
DOI: 10.1038/mt.2008.23
发表时间: 2008-05-01
期刊: MOLECULAR THERAPY
影响因子: 12.4
作者: [Kawano, Ryoko, Ishizaki, Masatoshi, Uchino, Makoto]
通讯作者: Uchino, Makoto
Amyotrophic lateral sclerosis in a patient with Kartagener syndrome
卡塔格纳综合征患者的肌萎缩侧索硬化症
DOI: --
发表时间: 2010
期刊: Amyotroph Lateral Scler
影响因子: --
作者: [Sumioka, A, Yamashita S]
通讯作者: Yamashita S
22
    Raman spectroscopic observation of a single polymer chain
    • 批准号:
      23655211
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.58万
    • 财政年份:
      2011
    • 负责人:
      MAEDA Yasushi
    • 依托单位:
    Study of nano-hetero interface of electrode catalysts
    Application of DNA self-assembly to nanoparticle-supported catalysts
    Raman spectroscopic observation of a single polymer Ghain by using surface plasmon resonance enhancement
    • 批准号:
      20550109
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2008
    • 负责人:
      MAEDA Yasushi
    • 依托单位:
    海外基金