Neurodegenerative mechanism and treatment with MOCA.

神经退行性病变机制及 MOCA 治疗。

• 批准号: 20200012
• 负责人: NAMEKATA Kazuhiko
• 金额: $ 19.14万
• 依托单位: Tokyo Metropolitan Organization for Medical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20200012/
• 关键词: 再生治療; 神経変性疾患; Dock3; WAVE; BDNF; 軸索再生; 視神経; MOCA; 神経化学; 生体機能利用; 再生医学; トランスジェニックマウス; 軸策伸長

Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.

Dock3通过刺激WAVE复合物的膜募集诱导轴突生长。

项目成果

Expression of Epiplakin1 in the developing and adult mouse retina

• DOI: 10.1007/s10384-009-0751-y
• 发表时间: 2010-02
• 期刊: Japanese Journal of Ophthalmology
• 影响因子: 2.4
• 作者: Tetsu Yoshida;Xiaoli Guo;K. Namekata;Y. Mitamura;S. Kume;T. Harada

Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy.

• DOI: 10.1016/j.diabres.2009.12.008
• 发表时间: 2010-03
• 期刊: Diabetes research and clinical practice
• 影响因子: 5.1
• 作者: Natsuyo Yoshida-Hata;Y. Mitamura;T. Oshitari;K. Namekata;C. Harada;T. Harada;S. Yamamoto

Interleukin-1 stimulates glutamate uptake in glial cells by accelerating membrane trafficking of Na^+/K^+-ATPase via actin depolymerization

Interleukin-1 通过肌动蛋白解聚加速 Na^ /K^ -ATP 酶的膜运输，从而刺激神经胶质细胞中谷氨酸的摄取

• 期刊: Molecular and cellular biology (In press)
• 作者: T.Saito;N.Iwata;S.Tsubuki;Y.Takaki;J.Takano;S-M Huang;T.Suemoto;M.Higuch;T.C.Saido;Harada T;Nakamura K;Namekata K.;Harada C.;Nakamura K.;Harada C.;Mitamura Y.;Nakamura K.;Harada C.;Kase S.;Namekata K
• 通讯作者: Namekata K

Expression of epiplakinl in the developing and adult mouse retina.

Epiplakinl 在发育中和成年小鼠视网膜中的表达。

• 发表时间: 2010
• 期刊: Japanese Journal of Ophthamology 54
• 作者: Yoshida T.;Guo X.;Namekata K.;Mitamura Y.;Kume S.;Harada T
• 通讯作者: Harada T

ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma

• DOI: 10.1038/cdd.2010.62
• 发表时间: 2010-11-01
• 期刊: CELL DEATH AND DIFFERENTIATION
• 影响因子: 12.4
• 作者: Harada, C.;Namekata, K.;Harada, T.
• 通讯作者: Harada, T.