Organization and basic functional mechanism of cerebellar modules

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The cerebellar module is organized by the molecular expression pattern and input-output axonal connections of Purkinje cells, climbing fibers and mossy fibers. We related axonal connections of Purkinje cells and mossy fiber axons that originate from the dorsal column nuclei to the aldolase C expression pattern. Combining the results with our previous findings on the climbing fiber projection pattern, we clarified the organization of cerebellar modules, and show how cerebellar input and output functions are correlated topographically. Furthermore, we have shown similarity of the cerebellar modular organization between rodents and primates by analyzing the marmoset cerebellum in addition to the rat cerebellum.