Positive and negative reward coding by serotonin, acetylcholine, and dopamine network.

血清素、乙酰胆碱和多巴胺网络的正向和负向奖励编码。

• 批准号: 20300139
• 负责人: NAKAMURA Kae
• 金额: $ 6.74万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300139/
• 关键词: ドパミン; セロトニン; アセチルコリン; 強化学習; 報酬; 脚橋被蓋核; 縫線核; 霊長類; モノアミン神経伝達物質; 嫌悪; 眼球運動; サル; reinforcement learning

The strength of firing of midbrain dopaminergic neurons has been revealed that it carries reward prediction error signal in the framework of reinforcement learning where an agent chooses actions to maximize rewards. The dopamine neurons receive inputs from the pedunculopontine tegmental nucleus(PPTN), where many cholinergic neurons exist, and the dorsal raphe nucleus(DRN), where many serotonergic neurons exist. Thus we measured single neuronal activity of PPTN and DRN while monkeys performed eye movement tasks to obtain reward of different values and the Pavlovian conditioning task in which appetitive and aversive events were imposed. We found that while different PPTN neurons encoded predicted reward and actual rewards separately, DRN neurons often carried predicted and actual rewards by single neurons. Such different reward signals may be fed and integrated in the dopamine neurons to compute reward prediction error signal, which is used for the control of action and decision making.

中脑多巴胺能神经元的放电强度已经被揭示，它在强化学习的框架中携带奖励预测错误信号，其中代理选择动作以最大化奖励。多巴胺神经元接受来自脚桥被盖核（PPTN）和中缝背核（DRN）的输入，脚桥被盖核（PPTN）中存在许多胆碱能神经元，中缝背核（DRN）中存在许多胆碱能神经元。因此，我们测量单个神经元活动的PPTN和DRN，而猴子进行眼动任务，以获得奖励的不同价值观和巴甫洛夫条件反射任务中的食欲和厌恶的事件施加。我们发现，虽然不同的PPTN神经元分别编码预测奖励和实际奖励，但DRN神经元通常由单个神经元携带预测和实际奖励。这种不同的奖励信号可以被馈送并集成到多巴胺神经元中以计算奖励预测误差信号，其用于控制动作和决策。

项目成果

Pedunculopontine Tegmental Nucleus Neurons Signal Predicted and Actual Reward for Reinforcement Learning

桥脚被盖核神经元信号预测和强化学习的实际奖励

• 发表时间: 2008
• 作者: Ken-ichi Okada;Yasushi Kobayashi;芳賀洋一;Yasushi Kobayashi
• 通讯作者: Yasushi Kobayashi

Positive and negative reward value coding in the primate lateral hypothalamus.

灵长类下丘脑外侧的正奖励值和负奖励值编码。

• 发表时间: 2010
• 作者: Noritake;A.;Nakamura;K.
• 通讯作者: K.

サル背側縫線核における報酬および嫌悪刺激の情報表現Neuronal coding of rewarding and aversive stimuli in the primate dorsal raphe mucieus

灵长类中缝背侧粘液奖励和厌恶刺激的神经元编码

• 发表时间: 2010
• 作者: Hayashi;K;. Nakao;K.;Okada;K.;Kobayashi;Y.;Nakamura;K.
• 通讯作者: K.

Saccadic eye movements as a neural correlate measure of preparatory set in children with ADHD

扫视眼球运动作为 ADHD 儿童准备组的神经相关测量

• 发表时间: 2010
• 作者: Yuri Kitamura;Yuka Matsuo;Masako Taniike;Ikuko Mohri;Yasushi Kobayashi;Kanehisa Morimoto
• 通讯作者: Kanehisa Morimoto

The pedunculopontine tegmental nucleus neurons encode predicted reward signal by tonic regular firing and given reward signal phasically

脚桥被盖核神经元通过强直规律放电和阶段性给予奖励信号来编码预测奖励信号

• 发表时间: 2011
• 作者: Kobayashi;Y. and Okada;K
• 通讯作者: K