Can higher brain activity modify exercise pressor reflex? -application of awake-sleep cycle to changing brain activity

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The present study has revealed that central command, originating from higher brain centers, plays an important role in controlling the cardiovascular system during voluntary exercise in daily life. In particular, the cardiovascular control by central command is prominent during flexion than extension movement. On the other hand, exercise pressor reflex originating from contacting skeletal muscles are suppressed in the conscious condition. However, muscle mechano- and metaboreflex become evident during sleep or anesthesia, suggesting that an inhibition of higher brain activity facilitates exercise pressor reflex. The brain serotonergic receptor system (especially, 5-HT_<1A> receptors) may be involved in the facilitation of the exercise pressor reflex.