Cardiac sympathetic nerve control of cardiac output during 24-hour period

心脏交感神经控制24小时内的心输出量

基本信息

批准号：
10670044
负责人：
MATSUKAWA Kanji
金额：
$ 1.54万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670044/
关键词：
Cardiac sympathetic nerve activity Autonomic nerve control Heart rate Stroke volume Cardiac output Arterial blood pressure Total peripheral Resistance 24-hour period 神経性制御抹消血管抵抗

项目摘要

We hypothesized that sympathetic outflows to different vascular beds or organs are specifically and differentially controlled in accordance with the physiological function of an individual vascular bed or organ. Such fine control of the sympathetic nervous system will be revealed by direct measurements of sympathetic outflows to different organs (such as the heart and the kidneys) during voluntary behavior in daily life.The present study was therefore undertaken to determine the responses in cardiac sympathetic nerve activity (CSNA) and renal sympathetic nerve activity (RSNA) during voluntary behavior in conscious cats and to identify the cause-effect relationships between CSNA and cardiac output (CO) and between RSNA and total peripheral vascular resistance (TPR). A pair of electrodes was implanted on the inferior cardiac nerve or the renal nerve and a Doppler flow probe was placed on the ascending aorta. Catheters were inserted into the left carotid artery and jugular vein. Three to … More ten days after the surgery, CSNA or RSNA, ascending aortic blood flow, mean arterial blood pressure (MAP) and heart rate (HR) were simultaneously measured for 5 hour in the unrestrained condition. CO, stroke volume (SV), and TPR were sequentially calculated. The sympathetic nerve and hemodynamic responses to a variety of voluntary behaviors (treadmill exercise, eating, drinking, and sleep) were analyzed.During treadmill exercise, HR and CO increased in proportion to the exercise speed. MAP did not change during exercise with a slow speed of 10-30 m/min and tended to rise gradually during exercise at a faster speed of 40-50 m/min. Thus calculated TPR tended to decrease during exercise. Propranolol blunted the tachycardia and almost abolished the increase in CO during treadmill exercise, suggesting cardiac sympathetic activation. Indeed, we found that CSNA increased during treadmill exercise, in accordance with the responses in HR and CO.It was interesting that RSNA showed no change during exercise at the slow speed and increased at the faster speed. In contrast to treadmill exercise, MAP increased considerably during eating and drinking while HR and CO increased slightly, suggesting a marked increase in TPR.On the other hand, MAP decreased considerably during sleep while HR and CO showed litle changes, suggesting a reduction in TPR.In consistent with the hemodynamic responses, RSNA was augmented during eating and drinking but was inhibited during sleep ; the responses in RSNA were greater than those in CSNA.It is concluded that sympathetic outflows to the heart and the kidneys are separately and differentially regulated during a variety of voluntary behaviors in daily life, suggesting fine control of the sympathetic nervous system by the brain cardiovascular center. Less

我们假设，根据单个血管床或器官的物理功能，对不同血管床或器官的交感神经渠道具有明确的和不同的控制。 Such fine control of the sympathetic nervous system will be revealed by direct measurements of sympathetic outlets to different organs (such as the heart and the kidsneys) during voluntary behavior in daily life.The present study was therefore undertaken to determine the responses in cardiac sympathetic nerve activity (CSNA) and renal sympathetic nerve activity (RSNA) during voluntary behavior in consciousness cats and to identify the cause-effect relationships between CSNA and cardiac output （CO）以及RSNA和总周围血管抗性（TPR）。将一对电子植入下心神经或肾神经，并将多普勒流量探针放在上升主动脉上。将导管插入左颈动脉和颈静脉中。手术后十天，CSNA或RSNA升高了三到…，在不受约束的情况下，仅测量了5小时的5小时，升高主动脉血流，平均动脉血压（MAP）和心率（HR）。依次计算CO，中风体积（SV）和TPR。分析了对各种自愿行为（跑步机，饮食，饮酒和睡眠）的交感神经和血液动力学反应。进行跑步机运动，人力资源和CO与运动速度成比例增加。在运动过程中，地图没有变化，速度为10-30 m/min，并且在运动过程中以40-50 m/min的速度逐渐上升。该计算的TPR在运动过程中倾向于减少。普萘洛尔削弱了心动过速，几乎消除了跑步机运动中CO的增加，表明心脏交感神经激活。确实，我们发现，根据HR和CO的响应，CSNA在跑步机运动过程中增加了，这很有趣，因为RSNA在慢速运动过程中没有显示出任何变化，并且以更快的速度增加。与跑步机运动相反，在饮食和饮用过程中，MAP谨慎地增加了，而人力资源部和CO略有增加，这表明另一方面的TPR显着增加，在睡眠期间，MAP仔细地减少了，而HR和CO显示了LITLE的变化，表明TPR.in的减少与血液动力学反应相一致，在饮食和饮用过程中，RSNA在睡眠期间被抑制了RSNA，在睡眠期间被抑制； RSNA中的反应大于CSNA中的反应。得出的结论是，在日常生活中各种自愿行为期间，对心脏的交感神经和孩子在各种自愿行为期间受到不同的调节，这表明大脑心血管中心对交感神经系统进行了很好的控制。较少的