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Effects of amino acid administration and exercise on the regulation of the muscle protein and energy metabolism.

氨基酸施用和运动对肌肉蛋白质和能量代谢调节的影响。

基本信息

批准号：
20300216
负责人：
SHIMOMURA Yoshiharu
金额：
$ 12.23万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300216/
关键词：
分岐鎖アミノ酸(BCAA)分岐鎖α-ケト酸脱水素酵素(BCKDH)BCKDHキナーゼ廃用性筋萎縮ラットヒラメ筋タンパク質合成促進因子ミトコンドリア高脂肪食インスリン抵抗性耐糖能ロイシン後肢懸垂筋タンパク質 BCAA 分岐鎖α-ケト酸脱水素酵素複合体 BCAA食総RNA

项目摘要

The metabolic control by nutrition and exercise may play important roles in the health promotion, and its correct information in regard to the responsible mechanisms for the effects are required. In the present studies, we addressed to clarify effects of branched-chain amino acid (BCAA) administration and exercise on the health promotion and the responsible mechanisms for the effects : the detailed aims were to clarify (1) the regulatory mechanism responsible for the BCAA metabolism, (2) the effects of BCAA administration on the disuse-induced muscle atrophy, and (3) the function of BCAA on the glucose metabolism. We found the evidence that suggests the existence of an unknown factor which may regulate the BCAA catabolism through inactivation of the branched-chain α-keto acid dehydrogenase kinase in rat liver mitochondria. In the study for the disuse-induced muscle atrophy, we found that the feeding of 5% BCAA diet attenuated disuse-induced decreases in the factors that promote cell growth and protein synthesis, although it did not affect the muscle atrophy itself and amounts of the components in the ubiquitin-proteasome system. Furthermore, we found that the plasma BCAA concentrations may play an important role in the normal glucose tolerance.

通过营养和运动进行的代谢控制可能在健康促进中发挥重要作用，并且需要关于其作用机制的正确信息。在本研究中，我们致力于阐明支链氨基酸（BCAA）给药和运动对健康促进的影响及其影响机制：具体目标是阐明（1）BCAA代谢的调节机制，（2）BCAA给药对废用性肌肉萎缩的影响，以及（3）BCAA对葡萄糖代谢的功能。我们发现证据表明存在一种未知因素，该因素可能通过大鼠肝线粒体中支链α-酮酸脱氢酶激酶的失活来调节支链氨基酸分解代谢。在废用性肌肉萎缩的研究中，我们发现饲喂5% BCAA饮食可以减弱废用性诱导的促进细胞生长和蛋白质合成的因子的减少，尽管它并不影响肌肉萎缩本身和泛素-蛋白酶体系统中成分的数量。此外，我们发现血浆BCAA浓度可能在正常糖耐量中发挥重要作用。