Detection of miRNAs using artificial oligonucleotide probes capable of chain length discrimination

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Artificial oligonucleoptide probes were developed for the detection of mature miRNA in living cells. The new nucleic acids derivatives such as the oligonucleotide probes having short RNA selectivity, the nucleic acid analogs capable of precise base recognition and the fluorescent nucleic acids applicable for the monitoring of the hybridization events were developed. These artificial nucleic acids are useful for the miRNA detection.