Development of functional surface structure and lubrication ability in articular cartilage tissue under tribologycal stimulation

探讨了关节软骨表层组织结构对摩擦刺激的功能适应过程和机制。一个良好建立的三维培养系统分离的软骨细胞，软骨细胞-琼脂糖结构，作为再生软骨模型和机械刺激，如循环压缩，剪切和表面摩擦，施加到模型，以检查其对细胞代谢和关节润滑功能组织结构的后续发展的影响。

Process and mechanism in the functional adaptation of superficial zone tissue structure of articular cartilage to tribological stimulations was explored. A well established three dimensional culture system for isolated chondrocytes, chondrocyte-agarose construct, was employed as a regenerated cartilage model and mechanical stimulations, such as cyclic compression, shear and surface friction, were applied to the model to examine their effects on cell metabolisms and the subsequent development of functional tissue structure for joint lubrication.