Immune regulation by the IL-6/IL-12 family cytokines

IL-6/IL-12家族细胞因子作为促炎细胞因子、辅助性T细胞分化诱导剂和效应分子在免疫应答的调节中发挥重要作用。在本研究中，我们阐明了这些细胞因子产生和发挥其生物学反应的分子机制，在各种疾病模型中的作用，以及这些细胞因子临床应用的可能性和一种新的复合分子的鉴定。因此，本研究结果将为包括癌症和自身免疫性疾病在内的各种疾病的治疗以及新细胞因子的鉴定开辟新的途径。

The IL-6/IL-12 family cytokines play an important role in the regulation of immune responses as pro-inflammatory cytokines, inducers of helper T differentiation, and effector molecules. In the present study, we elucidated the molecular mechanisms whereby these cytokines are produced and exert their biological responses, the role in various disease models, and the possibility of clinical application of these cytokines and the identification of a novel composite molecule. Therefore, the present results will open up a novel avenue to the therapy of various diseases including cancer and autoimmune diseases as well as the identification of a new cytokine.