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Elucidation and regulation of signal-propagation mechanisms in receptor proteins

Elucidation and regulation of signal-propagation mechanisms in receptor proteins
受体蛋白信号传播机制的阐明和调控
批准号:
20370059
负责人:
IMAMOTO Yasushi
金额:
$13.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Proteins change their conformations in response to various kinds of stimuli. To reveal the intramolecular interaction that induces the protein conformational change, the amino acid residues which are responsible for the protein conformational changes of photoreceptor proteins in bacteria and animal retina were identified. Based on these findings, the protein conformation was mechanically controlled by a linker whose length is changed by photo-isomerization to regulate the activity of the protein.
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会议论文
蛋白質構造変化の伝播メカニズム「生物における光情報変換の一般性と多様性」
蛋白质结构变化的传播机制“生物体内光信息转换的共性和多样性”
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Imamoto, Y., 今元泰]
通讯作者: 今元泰
DOI: 10.1529/biophysj.107.123414
发表时间: 2008-05-01
期刊: BIOPHYSICAL JOURNAL
影响因子: 3.4
作者: [Imamoto, Yasushi, Tatsumi, Sanae, Kataoka, Mikio]
通讯作者: Kataoka, Mikio
光センサー蛋白質の物性と機能メカニズム
光传感器蛋白的物理性质和功能机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Imamoto Y, Tatsumi S, Harigai M, Yamazaki Y, Kamikubo H, Kataoka M., 今元泰]
通讯作者: 今元泰
Association of Rhodopsin and Regulatory Protein
视紫红质与调节蛋白的关联
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [TejedorML, MizunoH, TsuyamaN, HaradaT, MasujimaT, Y. Imamoto]
通讯作者: Y. Imamoto
20
    Analysis of protein folding and conformational change based on the characterization of the transition state
    • 批准号:
      24657103
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      IMAMOTO Yasushi
    • 依托单位:
    Activation mechanisms of G-protein-coupled receptors based on the structural dynamics
    • 批准号:
      23370070
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $13.06万
    • 财政年份:
      2011
    • 负责人:
      IMAMOTO Yasushi
    • 依托单位:
    Studies on the Photoreactions and Tertiary Structure of Yellow Protein by Use of the Site-Directed Mutagenesis
    • 批准号:
      09833004
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.79万
    • 财政年份:
      1997
    • 负责人:
      IMAMOTO Yasushi
    • 依托单位:
    海外基金