Elucidation of immunoregulatory function of intestinal immunoregulatory cells and its application to anti-infectious and anti-allergic food

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In this study, we tried to elucidate the immune regulating functions of intestinal regulatory cells . This should be important in the development of novel immune functional foods. We examined the response of dendritic cells of Peyer's patch, an intestinal immune organ, to microbial components, analyzed the characteristics of CD3^-IL-2R^+ cells, a unique cell population in the intestine, and established an infection mouse model. We further elucidated the function of two types of regulatory T cells induced in oral tolerance, which is a suppressive mechanism of food allergy, and demonstrated the role of dendritic cells in its induction.